Lactate Dehydrogenase (LD, LDH). . .an intracellular enzyme that is widely distributed in the tissues of the body, particularly in the kidney, heart, skeletal muscle, brain, liver, and lungs. Increases in the value usually indicate cellular death and leakage of the enzyme from the cell.
Elevated LDH levels are nonspecific, but useful in confirming Myocardial Infarct or Pulmonary Infarct when viewed in relation to other test findings. For example, LDH remains elevated longer than CK, in MI. Can be broken down into five isoenzymes, but when values are reported or quoted, total LDH is meant.
Normal adult: 140-280 U/L
5mL venous blood sample. Serum is used.
Increased levels: 36-55 hrs after MI, 24 hrs within pain onset in pulmonary infarct, CHF, liver dis, malignancies, hypothyroidism, lung disease, muscular dystrophy, anemias, DTs, shock, hyperthermia, renal infart, CNS dis, pancreatitis, fractures, intestinal obstruction.
Decreased levels: good response to cancer therapy.
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