Cosyntropin Stimulation. . .Detects adrenal insufficiency after cortisone stimulation. Cosyntropin and Cortrosyn are synthetic subunits of Adrenocorticotropin Hormone (ACTH) that exhibits the full corticosteroid-stimulating effect of ACTH in healthy persons. Failure to respond is an indication of adrenal insufficiency.
Normal value: Cortisol: >20 ug/dL (>552 nmol/L) rise after Cosyntropin/Cortrosyn administration.
4mL fasting venous blood sample before administration of stim drug. 4mL sample at 30 and 60 minutes after administration.
Absence or blunted response to stim: Addison's dis, hypopituitarism, adrenal ca, adrenal insufficiency - possible sepsis picture.
Response to stim: adrenal hyperplasma.
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