Multiple Organ Dysfunction Syndrome

MODS. . .results from perfusion abnormalities and/or altered oxygen uptake by cells during sepsis and SIRS. MODS is considered a syndrome because the s/s are multiple and progressive. Organ systems are considered dysfunctional when they cannot maintain homeostasis or when they require supportive therapies to maintain homeostasis. The degree of organ dysfunction is a continuum that includes the possibility of return to normal function. The major organ systems affected in MODS are the pulmonary, renal, hepatic, cardiovascular, and CNS.

Disseminated Intravascular Coagulation

DIC. . .a result of unregulated clotting and thrombolysis stimulated by cytokine and/or pathogen toxin injury to the vascular endothelium during sepsis and SIRS.